The Protein Conferring Resistance to Antibiotics Found

Scientists in Paris have solved the structure of the proteins that allow bacteria to gain resistance to multiple antibiotics.  The growing resistance to multiple bacteria –ranging from TB to MRSA – has sprung an enormous amount of attention in the healthcare community and the general public.  A team of scientists from the University Paris Descartes have recently claimed to have solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics, according to a report in EMBO reports this month. This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.

Frédéric Dardel and colleagues crystallized both the narrow and broad-spectrum resistance forms of the antibiotic-modifying acetyltransferase enzyme. Their new study reveals that this particular enzyme has a flexible active site that can evolve to accommodate new antibiotics, allowing the bacteria to break them down and render them useless in killing off an infection. This type of enzyme is now carried by millions of bacteria struggling for survival in the antibiotic age.

More importantly, the research provides new insight for the design of new antibiotics that could evade this form of resistance, and new inhibitors that would extend the effectiveness of current antibiotics, both of which could help in the fight against the deadly infections becoming more frequent in hospitals.